Huang Lab

The Huang Lab was established in 2009 at the University of Chicago and has since been active in conducting pharmacogenomic research. In 2017, our laboratory moved to the University of Minnesota, where we continue that research.

Our main research focus is translational pharmacogenomics with a particular interest in the pharmacogenomics of anticancer agents. By systematically evaluating the human genome and its relationships to drug response and toxicity, our goal is to develop clinically useful models that predict risk for adverse drug reactions and nonresponse prior to administration of chemotherapy. Specifically, the theme of our research evolved around the idea of cell-based pharmacogenomics, which utilizes in vitro models for biomarker discovery and prediction-model construction, followed by in vivo validation. We routinely use cell lines (derived from healthy and diseased individuals as well as commercially available cancer cell lines) and clinical samples to discover and functionally characterize genetic variation and gene, miRNA, and long noncoding RNA expression for their roles in drug sensitivity.

Lab Announcements

Congratulations on the New Publication, Alex!

Congratulations to Alex on his newest publication in Nature Communications, titled, "Computationally predicting clinical drug combination efficacy with cancer cell line screens and independent drug action." He has put much time and energy into this work and we are very proud to see what it is today!

 

 

Alex Ling and Huang RS.  Computationally predicting clinical drug combination efficacy with cancer cell line screens and independent drug action. Nature Communications, 2020. In press.

Congratulations on the New Publications, Yingbo, Alex, and Siddhika!

Congratulations to Yingbo, Alex, and Siddhika, on their new publication in Translational Research: the journal of laboratory and clinical medicine titled "Oncogene or tumor suppressor? -- Long Noncoding RNAs role in Patient's Prognosis Varies Depending on the Disease Type." We look at how high expression of various lncRNAs can be associated with better or worse survival in certain types of cancers, among other prognostic roles. More information can be found here.

 

Congratulations, Asmaa!

Congratulants to Asmaa on winning the 2019-2020 MSCO(Minnesota Society of Clinical Oncology) Fellow Award for her work titled “The role of long non-coding RNA ANRIL in chemosensitivity in osteosarcoma and clinical outcomes”! 

Congratulations, Alex!

Congratulations to Alex on not only being selected as a finalist for the Life Sciences & Engineering Poster Presentation at the Minnesota Supercomputing Institute (MSI) Research Exhibition last week, but received first place! There were many incredible presentations, which really highlights how well he did. Congratulations!

To see past announcements, visit our archives here!