The Huang Lab was established in 2009 at the University of Chicago and has since been active in conducting pharmacogenomic research. In 2017, our laboratory moved to the University of Minnesota, where we continue that research.
Our main research focus is translational pharmacogenomics with a particular interest in the pharmacogenomics of anticancer agents. By systematically evaluating the human genome and its relationships to drug response and toxicity, our goal is to develop clinically useful models that predict risk for adverse drug reactions and nonresponse prior to administration of chemotherapy. Specifically, the theme of our research evolved around the idea of cell-based pharmacogenomics, which utilizes in vitro models for biomarker discovery and prediction-model construction, followed by in vivo validation. We routinely use cell lines (derived from healthy and diseased individuals as well as commercially available cancer cell lines) and clinical samples to discover and functionally characterize genetic variation and gene, miRNA, and long noncoding RNA expression for their roles in drug sensitivity.
Lab Announcements
Congratulations! Huang Lab Awarded Translational Research Funding!
UMN MCC CRTI Exceptional Translational Research Award (2025–2026)
Project Title: Exploiting Intratumoral Heterogeneity and Single-Cell Drug Prediction Models to Achieve Precision Oncology in Prostate Cancer
PIs: Dr. Stephanie Huang and Dr. Antonarakis
Translational Product Development Fund (TPDF-25-023, 2026–2028)
Project Title: Implementing Single-Cell Drug Prediction Models on Clinical Specimens for Precision Medicine in Oncology
PIs: Dr. Stephanie Huang and Dr. Sampreeti Jena
Congratulations to Dr. Sampreeti Jena for her recent publication!
Title: Exploiting Intratumoral Heterogeneity and Single-Cell Drug Prediction Models to Achieve Precision Oncology in Prostate Cancer.
Jena S, Kim D, Lee AM, Zhang W, Zhan K, Li Y, Dehm SM, Huang RS. Novel mixed cancer-cell models designed to capture inter-patient tumor heterogeneity for accurate evaluation of drug combinations. Res Sq. 2025 May 16
Congratulations to Amy Paulson and Radwa Elmorsi on their recent publication!
Paulson, A.L.; Elmorsi, R.M.; Lee, A.M.; Huang, R.S. Combined XPO1 Inhibition and Parthenolide Treatment Can Be Efficacious in Treating Triple-Negative Breast Cancer. Int. J. Mol. Sci. 2025, 26, 10243.
Congratulations to Yuting!
Her abstract was selected for a poster and flash talk presentation at the Microbiome and Cancer Symposium. The top two presenters will receive a $1,500 travel award, to be announced at the closing of the symposium.
In addition, Yuting was selected as a CTSI Poster Session Travel Award recipient for her work titled “Effects of Intratumoral Microbiota on Chemotherapy Response in Colorectal Cancer.” These poster competitions are highly competitive, and this award highlights the outstanding quality and impact of Yuting’s research.
Celebrating Aaratrika Mondal's Excellence at the Scholars Forum!
We are pleased to announce TWO recent publications!!:
Paulson AL, Gruener RF, Lee AM, Huang RS. Discovery, Validation and Mechanistic Study of XPO1 Inhibition in the Treatment of Triple-Negative Breast Cancer. Cancers (Basel). 2024 Nov 27;16(23):3980. doi: 10.3390/cancers16233980. PMID: 39682167; PMCID: PMC11640544.
Huang Y, Shan Y, Zhang W, Printzis C, Pesce L, Maeser D, Stanhope C, Stranger BE, Huang RS. Sex differences in the molecular profile of adult diffuse glioma are shaped by IDH status and tumor microenvironment. Neuro Oncol. 2024 Oct 5:noae207. doi: 10.1093/neuonc/noae207. Epub ahead of print. PMID: 39367624.
Congratulations to Yuting!
We are very thrilled to announce the recent achievements by our lab member Yuting:
- For being selected as a 2024-2026 UMN CTSI Translational Research Development Program (TRDP) Grant awardee
- For being selected for the 2024-2025 Doctoral Dissertation Fellowship
- For being select for the 2024 ECP Zaske Fellowship winner
Congratulations!
We are pleased to announce that our lab scientist Dr. Adam Lee has been awarded the 2021 College of Pharmacy Meritorious Service Award; our lab member Yingbo Huang has been awarded the Fall 2022 TA of the Semester! Congratulations!
We are proud to announce Amy's successful defense of her preliminary exam! Congratulations on officially becoming a PhD candidate!
Congratulations to our lab PI, Dr. R. Stephanie Huang, for being promoted to professor with tenure in the Department of Experimental & Clinical Pharmacology!
Congratulations to Weijie on being awarded the 2022-2023 Interdisciplinary Doctoral Fellowship! Official announcement and more information can be found on 2022–2023 Interdisciplinary Doctoral Fellowship recipients announced
We are pleased to announce that Yingbo Huang has been awarded First Place in the Rho Chi Research Day! We are extremely proud of you and eager to see more of your good research work in the future.
Congratulations to Amy on passing her written preliminary exam. Good luck on your future defense and we are excited to see more good research from you!
Congratulations to Adam Lee, Asmaa Ferdjallah, Daniel Kim et al. on a manuscript offically being published in International Journal of Molecular Sciences! Titled "Long Non-Coding RNA ANRIL as a Potential Biomarker of Chemosensitivity and Clinical Outcomes in Osteosarcoma", check it out at https://www.mdpi.com/1422-0067/22/20/11168!
Congratulations to Amy on passing her written preliminary exam. Good luck on your future defense and we are excited to see more good research from you!
Congratulations on successfully passing your preliminary exams and becoming PhD candidates. Keep on kicking!
Archives
You can visit our announcement archives to see past announcements.