The Huang Lab was established in 2009 at the University of Chicago and has since been active in conducting pharmacogenomic research. In 2017, our laboratory moved to the University of Minnesota, where we continue that research.
Our main research focus is translational pharmacogenomics with a particular interest in the pharmacogenomics of anticancer agents. By systematically evaluating the human genome and its relationships to drug response and toxicity, our goal is to develop clinically useful models that predict risk for adverse drug reactions and nonresponse prior to administration of chemotherapy. Specifically, the theme of our research evolved around the idea of cell-based pharmacogenomics, which utilizes in vitro models for biomarker discovery and prediction-model construction, followed by in vivo validation. We routinely use cell lines (derived from healthy and diseased individuals as well as commercially available cancer cell lines) and clinical samples to discover and functionally characterize genetic variation and gene, miRNA, and long noncoding RNA expression for their roles in drug sensitivity.
Lab Announcements
We are happy to announce the three recent new publications:
Xia, Y., Ling, A. L., et al. A Web Application for Predicting Drug Combination Efficacy Using Monotherapy Data and IDACombo. Journal of Cancer Science and Clinical Therapeutics, 7, 253-258.
Ling, A. L., et al. Simplicity: web-based visualization and analysis of high-throughput cancer cell line screens. Journal of Cancer Science and Clinical Therapeutics, 7, 249-252.
Maeser, D., Zhang, W., Huang, Y., & Huang, R. S. (2024). A review of computational methods for predicting cancer drug response at the single-cell level through integration with bulk RNAseq data. Current Opinion in Structural Biology, 84, 102745.
Our lab member Dr. Yuting Shan has led a team to review sex differences in drug adverse reactions and published their work on Frontiers in Pharmacology. Congratulations!
We are very thrilled to announce the recent achievements by our lab members:
- Weijie Zhang was awarded the Doctoral Dissertation Fellowship.
- Yuting Shan was awarded the PGRN (Pharmacogenomics Global Research Network) presidential abstract award and will be giving a talk about her abstract in the PGRN 2023 annual meeting.
Congratulations to both!
To see past announcements, visit our archives here!